CHU Besançon Franche-Comté

Valorisation scientifique

​​​​​​Biothérapie

Areal bone mineral density, trabecular bone score and 3D-DXA analysis of proximal femur in psoriatic disease. Toussirot E, Winzenrieth R, Aubin F, Wendling D, Vauchy C, Desmarets M. Front Med (Lausanne). 2024 Jan 30;11:1341077. doi: 10.3389/fmed.2024.1341077. PMID: 38352141; PMCID: PMC10861729

Ziliotis MJ, Vauchy C, Deconinck E, Berceanu A, Büchler M, Caillard S, Couzi L, Dussol B, Frimat L, Hazzan M, Jaulin JP, Malvezzi P, Peffault de Latour R, Ducloux D, Courivaud C, Kidney Transplantation After Allogenic Hematopoietic Cell Transplantation. Kidney Int Rep. 2004 Jan 30 ;9(4) :1127-1131. doi :10.1016/j.ekir.2024.01.048. PMID :38765558 ;PMCID :PMC11101824

Kim S, Ghiringhelli F, De la Fourchardière C, Evesque L, Smith D, Badet N, Samalin E, Lopez-Trabada Ataz D, Parzy A, Desramé J, Baba Hamed N, Buecher B, Tougeron D, Bouché O, Dahan L, Chibaudel B, El Hajbi F, Mineur L, Dubreuil O, Ben Abdelghani M, Pecout S, Bibeau F, Herfs M, Garcia ML, Meurisse A, Vernerey D, Taïeb J, Borg C. Atezolizumab plus modified docetaxel, cisplatin, and fluorouracil as first-line treatment for advanced anal cancer (SCARCE C17-02 PRODIGE 60) : a randomised, non-comparative, phase 2 study. Lancet Oncol. 2024 Apr ;25(4) :518-528. doi :10.1016/S1470-2045(24)00081-0.PMID :38547895

Transfused Red Blood Cell Characteristics and Kidney Transplant Outcomes Among Patients Receiving Early Posttransplant Transfusion. Gaiffe E, Vernerey D, Bardiaux L, Leroux F, Meurisse A, Bamoulid J, Courivaud C, Saas P, Hazzan M, Tiberghien P, Ducloux D.JAMA Netw Open. 2023 Sep 5;6(9):e2332821. doi: 10.1001/jamanetworkopen.2023.32821.PMID: 37707816 

Pre-transplant immune profile defined by principal component analysis predicts acute rejection after kidney transplantation. Gaiffe E, Colladant M, Desmaret M, Bamoulid J, Leroux F, Laheurte C, Brouard S, Giral M, Saas P, Courivaud C, Degauque N, Ducloux D.Front Immunol. 2023 Jul 11;14:1192440. doi: 10.3389/fimmu.2023.1192440. eCollection 2023.PMID: 37497224

Desmarets M, Hoffmann S, Vauchy C, Rijnders BJA, Toussirot E, Durrbach A, Körper S, Schrezenmeier E, van der Schoot CE, Harvala H, Brunotte G, Appl T, Seifried E, Tiberghien P, Bradshaw D, Roberts DJ, Estcourt LJ, Schrezenmeier H. Early, very high-titre convalescent plasma therapy in clinically vulnerable individuals with mild COVID-19 (COVIC-19): protocol for a randomised, open-label trial. BMJ Open. 2023 Apr 27;13(4):e071277. doi: 10.1136/bmjopen-2022-071277. PMID: 37105693; PMCID: PMC10151238.

Toussirot E, Winzenrieth R, Aubin F, Wendling D, Vauchy C, Desmarets M. Areal bone mineral density, trabecular bone score and 3D-DXA analysis of proximal femur in psoriatic disease. Front Med (Lausanne). 2024 Jan 30;11:1341077. doi: 10.3389/fmed.2024.1341077. PMID: 38352141; PMCID: PMC10861729.

Innovation technologique

Bronnert R, Besch G, Hild O, Lihoreau T, Chaussy Y, Ferreira D. Performance of artificial intelligence models for predicting intraoperative complications during surgery in real time: a systematic review and meta-analysis protocol. BMJ Open. 2025 Oct 20;15(10):e106204. doi: 10.1136/bmjopen-2025-106204. PMID: 41120159; PMCID: PMC12542564.

Wacogne B, Vaccari N, Koubevi C, Azzopardi CL, Karib B, Rouleau A, Frelet-Barrand A. White Light Spectroscopy for Sampling-Free Bacterial Contamination Detection During CAR T-Cells Production: Towards an On-Line and Real-Time System. Biosensors (Basel). 2025 Aug 6;15(8):512. doi: 10.3390/bios15080512. PMID: 40862971; PMCID: PMC12384153.

Bernard N, Sagawa Y Jr, Bier N, Lihoreau T, Pazart L, Tannou T. Using artificial intelligence for systematic review: the example of elicit. BMC Med Res Methodol. 2025 Mar 18;25(1):75. doi: 10.1186/s12874-025-02528-y. PMID: 40102714; PMCID: PMC11921719.

Pretalli JB, Vernerey D, Evrard P, Pozet A, Clairet AL, Benoist S, Karoui M, Cotte E, Heyd B, Lakkis Z; FLUOCOL Study Group. Intraoperative indocyanine green fluorescence angiography in colorectal surgery to prevent anastomotic leakage: A single-blind phase III multicentre randomized controlled trial (FLUOCOL-01/FRENCH 21/GRECCAR 19 intergroup trial). Colorectal Dis. 2025 May;27(5):e70119. doi: 10.1111/codi.70119. PMID: 40415381; PMCID: PMC12104609.

Elouneg A, Lejeune A, Rolin G, Lihoreau T, Chatelain B, Bordas S, Jacquet E, Chambert J. Assessment of anisotropic mechanical response of human skin: insights from a clinical trial. Biomech Model Mechanobiol. 2025 Jun;24(3):1085-1102. doi: 10.1007/s10237-025-01955-6. Epub 2025 Jun 2. PMID: 40457020.

Gonod M, Suarez MA, Laskri S, Rolin G, Charriere K, Dordor E, Crouzilles J, Lihoreau T, Pazart L, Vinchant JF, Aubignac L, Grosjean T. Seven-probe fiber detector for time-resolved source tracking in HDR-brachytherapy: Pre-clinical experimental evaluation. Med Phys. 2025 Nov;52(11):e70080. doi: 10.1002/mp.70080. PMID: 41206357.

Garin A, Béjean M, Saleh Y, Picard R & Lihoreau T (2024). Une métrique de maturité pour aligner les acteurs d’écosystèmes d’innovation en santé : Le cas des Concept Maturity Levels. Journal de gestion et d'économie de la santé, 42 (4), 69-87. https://doi.org/10.54695/jdds.042.4.0069

Pazart L., Armbruster V., Monin D., Delorme C., Borel M., Nihouannen D., Barbot F., Bouquet F., Carrault G., Lihoreau T., Durand M., Clogenson H. and Pelayo S. (2024). Promote Competency-Based Training Approach in Quality, Regulatory and Clinical Affairs to Improve MD/IVDD Safety and Performance. In Proceedings of the 17th International Joint Conference on Biomedical Engineering Systems and Technologies - Volume 1: ClinMed; ISBN 978-989-758-688-0, SciTePress, pages 842-851. DOI: 10.5220/0012593900003657

Santé mentale et neurosciences

Béreau M, Kibleur A, Servant M, Clément G, Dujardin K, Rolland AS, Wirth T, Lagha-Boukbiza O, Voirin J, Santin MDN, Hainque E, Grabli D, Comte A, Drapier S, Durif F, Marques A, Eusebio A, Azulay JP, Giordana C, Houeto JL, Jarraya B, Maltete D, Rascol O, Rouaud T, Tir M, Moreau C, Danaila T, Prange S, Tatu L, Tranchant C, Corvol JC, Devos D, Thobois S, Desmarets M, Anheim M. Motivational and cognitive predictors of apathy after subthalamic nucleus stimulation in Parkinson's disease. Brain. 2024 Feb 1;147(2):472-485. doi: 10.1093/brain/awad324.PMID: 37787488

Béreau M, Castrioto A, Servant M, Lhommée E, Desmarets M, Bichon A, Pélissier P, Schmitt E, Klinger H, Longato N, Phillipps C, Wirth T, Fraix V, Benatru I, Durif F, Azulay J-P, Moro E, Broussolle E, Thobois S, Tranchant C, Krack P, Anheim M (2023) Imbalanced motivated behaviors according to motor sign asymmetry in drug-naïve Parkinson's disease. Sci Rep 13:21234.

Cabeza L, Mor D, Ramadan B, Benhora-Chabeaux G, Houdayer C, Haffen E, et al. Neurogliovascular unit adaptations following chronic distress predict motivational deficits in mice. Prog Neuropsychopharmacol Biol Psychiatry. 2 oct 2025;142:111510. doi:10.1016/j.pnpbp.2025.111510 PubMed PMID: 41005428.

Cramoisy S, Cabeza L, Ramadan B, Houdayer C, Haffen E, Belin D, et al. Cumulative effect of stress on decisional exploration-to-exploitation switch assessed through a gambling task in female mice. Brain Res. 1 mai 2025;1854:149546. doi:10.1016/j.brainres.2025.149546 PubMed PMID: 40043786.

de Cock C, Boillot S, Trimaille H, Thiriez G, Chassagne A, Clement A. [Experiences of parents of premature infants in their feeding journey]. Soins Pediatr Pueric. 2025;46(343):27‑31. doi:10.1016/j.spp.2025.01.008 PubMed PMID: 40089353.

Giffard M, Van Bulck L, Sall FS, Becoulet N, Seronde MF, Ecarnot F. Palliative care for cardiovascular patients: comparison of the motives of referral by cardiologists and the actual care provided by the mobile palliative care team. Eur Geriatr Med. avr 2025;16(2):721‑6. doi:10.1007/s41999-024-01143-2 PubMed PMID: 39922963.

Laidi C, Bouaziz N, Haffen E, Domenech P, Duchesnay E, Favre P, et al. [Brain imaging and the first success of precision psychiatry]. Med Sci MS. mai 2025;41(5):500‑7. doi:10.1051/medsci/2025061 PubMed PMID: 40418012.

Merienne A, Claude Roux P, Chassagne A. [Understanding teenagers’ experiences of asthma. A qualitative approach to adolescents’ perceptions of the disease and management of the symptoms]. Rev Mal Respir. janv 2025;42(1):53‑61. doi:10.1016/j.rmr.2024.10.007 PubMed PMID: 39665952.

Yrondi A, Javelot H, Nobile B, Boudieu L, Aouizerate B, Llorca PM, et al. French Society for Biological Psychiatry and Neuropsychopharmacology (AFPBN) guidelines for the management of patients with partially responsive depression and treatment-resistant depression: Update 2024. L’Encephale. févr 2025;51(1):26‑38. doi:10.1016/j.encep.2023.11.029 PubMed PMID: 38369426.

Darçot B, Nicolier M, Giustiniani J, Bennabi D, Haffen E, Vandel P, et al. Objective assessment of familiarity in music using imagery and EEG-based machine learning. Sci Rep. 6 mars 2026;16(1):8689. doi:10.1038/s41598-026-41988-0 PubMed PMID: 41792362; PubMed Central PMCID: PMC12979593.

Gabriel D, Bertrand G, Nicolier M, Giustiniani J. Neuroimaging of reality: A new approach for investigating neural bases of decision-making with real-world objects. J Neurosci Methods. 20 janv 2026;429:110692. doi:10.1016/j.jneumeth.2026.110692 PubMed PMID: 41571156.

Galli S, Poirson B, Bourdin H, Haffen E, Giustiniani J. Correlation between urinary 6-sulfatoxymelatonin and actigraphy data in a clinical population with sleep disorders: an observational study. Sleep Breath Schlaf Atm. 28 mai 2026;30(3):173. doi:10.1007/s11325-026-03706-y PubMed PMID: 42207368.

 Giustiniani J, Nicolier M, Maylié F, Pazart L, Haffen E, Gabriel D. Spatio-temporal differences in EEG dynamics during decision-making between online poker players with moderate-risk and high-risk gambling activity. Sci Rep. 5 avr 2026;16(1):16518. doi:10.1038/s41598-026-46508-8 PubMed PMID: 41936636; PubMed Central PMCID: PMC13216239.

Thellier-Francois J, Binda D, Nicolier M, Haffen E, Maillot MC, Pretalli JB, et al. Effectiveness of hypnosis in adults with posttraumatic stress disorder (PTSD). L’Encéphale. mars 2026;S0013700626000199. doi:10.1016/j.encep.2025.12.002

Trimaille H, Sagawa Y, Chassagne A. Autonomy, disruptions and coping strategies of community-dwelling older adults in food-related activities - food shopping, cooking and eating- a scoping review. J Nutr Health Aging. févr 2026;30(2):100769. doi:10.1016/j.jnha.2025.100769 PubMed PMID: 41512770; PubMed Central PMCID: PMC12816844.

Vionnet Rouxbedat N, Van Bulck L, Giffard M, Chassagne A. Understanding Heart Failure Patients’ Beliefs and Social Representations of Palliative Care and Advance Directives. Eur J Cardiovasc Nurs. 23 févr 2026;zvag055. doi:10.1093/eurjcn/zvag055 PubMed PMID: 41729755.